Tau fa'atau atoa 100% Pure Forsythiae Fructus suau'u Relax Aromatherapy Eucalyptus globulus

Fa'atau oloa tele 100% Pure Forsythiae Fructus oil Relax Aromatherapy Eucalyptus globulus Ata Fa'aalia

fa'amatalaga puupuu:

Forsythia suspensa(Thunb.) Vahl. (Family Oleaceae) o se laʻau teuteu, o fua o loʻo faʻaaogaina e pei o le TCM lauiloa "Forsythiae Fructus" (FF) (连翘in Saina). O uiga o le TCM o le FF o loʻo aoteleina e pei o le oona i le tofo, faʻatasi ai ma se natura malulu malulu ma le mama, fatu poʻo le intestinum meridian tufatufaga (Pharmacopoeia Commission of PRC, 2015), o na uiga e tutusa ma le uiga o le anti-inflammatory TCM, e tusa ai ma Chen ma Zhang (2014). I le la'au a Shennong, na fa'aaogaina ai le FF mo le togafitia o le pyrexia, mumu, gonorrhea, carbuncle ma erysipelas (Cho et al., 2011). E lua ituaiga o FF o lo'o maua, o le fua lanumeamata fou e ta'ua o le "Qingqiao" ma le samasama matua atoa e ta'ua o le "Laoqiao". O i latou uma e avea ma punaʻoa aloaʻia o le FF, ae ui i lea, o Qingqiao e faʻaaogaina soo i TCM faʻatonuga (Jia et al., 2015). O vaega tetele e gaosia ai le FF o Hebei, Shaanxi, Shanxi, Shandong, Anhui, Henan, Hubei, Jiangsu (fa'ato'aina) ma Sichuan Provinces (Editorial Board of Flora of China, 1978).

I le lomiga 2015 Chinese Pharmacopoeia, 114 Chinese medicinal preparations o loʻo i ai FF o loʻo lisiina, e pei ole Shuanghuanglian oral solution, Yinqiao Jiedu tablet, Niuhuang Shangqing tablets, etc (Pharmacopoeia Commission of PRC, 2015). O suʻesuʻega faʻaonaponei o loʻo faʻaalia ai lona anti-inflammatory (Kim et al., 2003), antioxidant (CC Chen et al., 1999), antibacterial (Han et al., 2012), anti-cancer (Hu et al., 2007), anti -virus (Ko et al., 2005), anti-allergy (Hao et al., 2010), neuroprotective (S. Zhang et al., 2015) aafiaga,ma isi.E ui lava e naʻo le fua o loʻo faʻaaogaina e avea ma TCM, o nisi suʻesuʻega na lipotia mai ai le phytochemistry ma le vailaʻau o lau (Ge et al., 2015, Zhang et al., 2015), fugalaau (Takizawa et al., 1981) ma fatu (Zhang et al. ., 2002) oF. suspensa. O le mea lea, matou te tuʻuina atu nei se faʻasalalauga faʻapitoa o faʻamatalaga avanoa oF. suspensa, e aofia ai faʻaoga masani, botany, phytochemistry, pharmacology, toxicity, pharmacokinetics ma le pulea lelei. E le gata i lea, o loʻo faʻatalanoaina le lumanaʻi o suʻesuʻega.

Vaega snippet

Fa'aoga masani

I tusitusiga masani o la'au a Saina, FF o lo'o fa'amauina e aoga i le togafitia o le fistula o isumu, scrofula, carbuncle, ma'i ma'i ma'i, gall tuma, vevela ma mea oona (Shennong's herbal, Bencao Chongyuan, Bencao Zhengyi, Zhenglei Bencao). E tusa ai ma le tele o tala fa'asolopito anamua, o lenei la'au fa'afoma'i e matua aoga tele i le fa'amamaina o le vevela o le fatu ma fa'asa'olotoina le susū-avela o le manava ma le manava. E faʻapitoa foʻi mo togafitiga o le stranguria, edema, qi stagnancy ma le toto stasis.

Botany

F. suspensa(Weeping Forsythia) o se la'au lauusiusi teuteu e tupuga mai i Saina, e o'o i le maualuga e tusa ma le 3 m (Fig. 1). E iai ona va'a 'o'o'o ma lala fa'alafolafoa'i e lanu samasama-enaena pe enaena-enaena. O lau e masani lava ona faigofie, ae o nisi taimi e 3-folilate. O lau laula'au e lapopo'a, lautele ovate, po'o elliptic-ovate ma 2-10 × 1.5-5 cm2 le lapopoa ma le lapotopoto i le cuneate pito ma se pito sili. O itu uma e lua o laulaau e lanumeamata, enaena ma maai pe maalili

Phytochemistry

I aso nei, 237 faʻalapotopotoga ua maua i totonuF. suspensa, e aofia ai le 46 lignans (1–46), 31 phenylethanoid glycosides (47–77), 11 flavonoids (78–88), 80 terpenoids (89–168), 20 cyclohexylethanol derivatives (169–188), ono alkaloids (189–194). ), fa steroidals (195-198) ma le 39 isi faʻapotopotoga (199-237). I totonu oi latou, e lua vaega (21–22) na vavae ese mai fugalaau oF. suspensa, 19 vaega (94–100, 107–111, 115–117, 198, 233–235) na vavae ese mai lau o leF. suspensa, fa vaega

A'afiaga fa'ama'i

O gaioiga faʻamaʻi faʻamaʻi a le FF e lagolagoina ai ona aʻafiaga o le vevela (Guo et al., 2015). O le fulafula o se tali faʻaletino i faʻamaʻi pipisi, faʻamaʻi, poʻo vailaʻau faʻamalosi (Lee et al., 2011). E auai i le atinaʻeina o faʻamaʻi tumau, e pei o faʻamaʻi paʻu, allergies, ma le kanesa,ma isi.O le FF o se tasi o le TCM e iai le malosi o le anti-inflammatory, e faʻaaogaina lautele i le faʻamaʻi masani ma le afaina. O gaioiga fa'ama'i fa'ama'i a le FF na fa'aigoaina le lima pito i luga i le 81 fa'ata'ita'iina TCM (70% ethanol

Oona

E oo mai i le taimi nei, e leai se lipoti o le oona o le FF. Ole fa'atonuga ole FF ile aso ole fa'atonuina ole 6-15 g (Pharmacopoeia Commission of PRC, 2015). O lipoti talafeagai na faailoa mai ai e leai se oona ogaoga o le vai poo le ethanol extract o lau oF. suspensai isumu, e oʻo lava ile fua ole aso ole 61.60 g/kg (Ai et al., 2011, Hou et al., 2016, Li et al., 2013). Han et al. (2017) na lipotia mai e leai se oona ogaoga o le phillyrin (mai lau oF. suspensa)i isumu NIH (18.1 g / kg / aso, po, mo le 14 aso) pe leai

Pharmacokinetics

Li et al. fa'ailoa mai e iva vaega I metabolites o le phillyrin i fa'ata'ita'iga urinary o isumu ma fa'ailoa ai ona ala fa'ato'a mafai i isumu. O le Phillyrin na muamua fa'apalapala i le phillygenin ona liua lea i isi metabolites e sili ona malosi e ala i le methylation, demethylation, dehydroxylation ma le tatalaina o mama (Li et al., 2014c). H. Wang et al. (2016) na faailoa mai ai le 34 vaega I ma le vaega II metabolites o le phillyrin ma faailoa mai o le hydrolysis, oxidation ma le sulfation e tele.

Pulea lelei

Ina ia pulea le lelei o le FF, o le Chinese Pharmacopoeia o loʻo fautua mai ai le faʻaogaina o le morphological, microscopic ma le TLC faʻaopoopo i le HPLC faʻamautinoa. O fa'ata'ita'iga FF agava'a e tatau ona iai le sili atu i le 0.150% phillyrin (Pharmacopoeia Commission of PRC, 2015).

Ae ui i lea, o le tasi fua faʻailoga, phillyrin, e foliga mai e le lava e iloilo ai le lelei o le FF. Talu ai nei, na suʻesuʻeina ai vaega eseese o meaola i totonu o le FF e ala i chromatography tulaga ese, electrophoresis, MS ma NMR metotia, pei ole

Fa'ai'uga ma va'aiga i le lumana'i

O le iloiloga o lo'o iai nei o lo'o aoteleina ai fa'amatalaga auiliili e uiga i le fa'aoga masani, botany, phytochemistry, pharmaceutical effects, toxicity, pharmacokinetics ma le pulea lelei o le.F. suspensa. I tusitusiga la'au masani a Saina ma le Chinese Pharmacopoeia, o le FF o lo'o fa'aaogaina tele mo le fa'amama vevela ma le fa'amama. E o'o mai i le taimi nei, e silia ma le 230 mea fa'afefiloi ua tu'u'ese'ese ma fa'ailoa mai i lenei la'au. Faatasi ai ma i latou, o lignans ma phenylethanoid glycosides ua manatu o se uiga ma meaola

TCM fa'amatalaga

Yin: "Yin" o se tasi o malosiaga faʻafeagai e lua o le natura, e tusa ai ma le fausaga a Saina anamua o le atulaulau. O le "Yin" o loʻo faʻamatalaina o le telegese, vaivai, gauaʻi, faʻasalalau, malulu, susu poʻo le toʻa, ma e fesoʻotaʻi ma vai, lalolagi, masina, fafine ma le po.

Qi: I faaupuga acupuncture, "qi" o le "malosi o le ola". O le fa'apogai o gaioiga uma i totonu o le tino, o le puipuiga mai osofa'iga a le tino, o le fa'apogai o gaioiga uma o le metabolic, e maua ai le taofiofia o a'a.

Fa'afetai

O lenei galuega na lagolagoina e le Beijing Joint Project of Science Research ma aʻoaʻoga faʻauʻu-Autu tekinolosi suʻesuʻega ma le faʻaogaina o le suʻesuʻeina o le saogalemu o vailaʻau oona Saina e faʻavae i luga o le vailaʻau ma uiga o le zebrafish.

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Fa'amatalaga Oloa

Faailoga o oloa

Ethnopharmacological talafeagai

Forsythiae Fructus (ta'ua Lianqiao i le gagana Saina), o le fua oForsythia suspensa(Thunb.) Vahl, o loʻo faʻaaogaina o se vailaʻau masani masani i Saina, Iapani ma Korea. E masani ona faʻaaogaina e togafitia ai le pyrexia, mumū,gonorrhea,carbunclemaerysipelas. Fa'alagolago i taimi eseese o le seleselega, e mafai ona fa'avasega Forsythiae Fructus i ni fo'i se lua, e ta'ua o Qingqiao ma Laoqiao. O fua lanumeamata e amata ona matua e aoina e pei o Qingqiao, ae o fua samasama ua matua atoatoa e aoina e pei o Laoqiao. O loʻo faʻaogaina uma i le faʻaaogaina faafomaʻi. O lenei iloiloga o lo'o fa'amoemoe e tu'uina atu se aotelega fa'atulagaina oF. suspensa(Forsythia suspensa(Thunb.) Vahl) ma ia faʻaalia le fesoʻotaʻiga i le va o faʻaoga masani magaioiga fa'afoma'iina ia ofoina atu musumusuga mo suʻesuʻega i le lumanaʻi.

Meafaitino ma metotia

Fa'amatalaga tutusa uma e uiga iF. suspensana su'esu'e e Scifinder ma maua mai fa'amaumauga fa'asaienisi e aofia ai Springer, Science Direct, Wiley, Pubmed ma Saina Knowledge Resource Integrated (CNKI). Sa su'esu'eina fo'i fa'asalalauga fa'alotoifale ma tusi.

I'uga

E tusa ai ma tusitusiga masani a Saina ma le Chinese Pharmacopoeia, Forsythiae Fructus o loʻo faʻaalia tele le faʻamamaina o le vevela ma le faʻamamaina o aʻafiaga i totonu.TCMtalavai. I suʻesuʻega faʻaonaponei, e sili atu i le 230 faʻalapotopotoga na tuʻueseese ma iloa maiF. suspensa. 211 O i latou na vavae ese mai fua.Lignansma le phenylethanoidglycosideso lo'o fa'atatauina o mea fa'apitoa ma malosi o lenei vao, e pei o le forsythiaside, phillyrin,masanima le phillygenin. Na latou faʻaalia le faʻamaʻi-inflammatory, antioxidant, antibacterial, anti-virus, anti-cancer and anti-allergy effects,ma isi.I le taimi nei, e leai se lipoti e uiga i le oona o Forsythiae Fructus, e ui lava i sina oona o forsythiaside o loʻo lipotia i lomiga faʻapitonuʻu. Pe a faatusatusa ia Laoqiao, Qingqiao o loʻo i ai tulaga maualuga o forsythiaside, forsythoside C, cornoside,masani, phillyrin,galic acidmachlorogenic acidma tulaga maualalo ole rengyol,β-glucose ma S-suspensasidemethyl eter.

Fa'ai'uga

O gaioiga e faʻamama ai le vevela a Forsythiae Fructus e faʻavae i luga o le anti-inflammatory ma antioxidant properties o lignans ma phenylethanoid.glycosides. O a'afiaga fa'amama e fa'atatau ile antibacterial, antiviral and anti-cancer activities a Forsythiae Fructus. Ma o uiga fa'a-Saina fa'aSaina (TCM) o le Forsythiae Fructus (oona oona, uiga malulu ma le mama meridian) na lagolagoina lona malosi e tetee atu ai i le mumu. E le gata i lea, o le anti-inflammatory mataʻina mamalosi o le antioxidanto Forsythiae Fructus fesoasoani i lona anti-kanesa maneuroprotectivegaoioiga. O le maualuga maualuga o lignans ma phenylethanoid glycosides i Qingqiao nai lo Laoqiao e mafai ona faʻamatalaina le sili atu le malosi o le antioxidant o Qingqiao ma le faʻaaogaina masani o Qingqiao i totonu.TCMtalavai. Mo suʻesuʻega i le lumanaʻi, sili atui le vivofa'ata'ita'iga ma su'esu'ega fa'afoma'i e fa'amalosia e fa'amanino atili le va o fa'aoga masani ma fa'aoga fa'aonaponei. E tusa ai ma Qingqiao ma Laoqiao, o loʻo tumau pea le faʻavasegaina e ala i auala uma e pulea lelei ai, ma e tatau ona faʻatusatusa le vailaʻau vailaʻau ma aʻafiaga i le va oi latou.